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After Sinead O’Connor’s tragic death last year, an ex partner yesterday insisted confirmation of her dying of natural causes means she died from a ‘broken heart’.

The star, 56, was found ‘unresponsive’ by police at her flat in Herne Hill, south-east London, in July last year – 18 months after her beloved 17-year old son Shane killed himself. On Tuesday officials ruled she had died of natural causes.

Dermot Hayes, who dated singer Sinead for two years after writing an early autobiography of her, told The Irish Sun: ‘From this you can surmise that a broken heart is a real illness symptom, and a cause of death.

‘It doesn’t make Sinead’s ­passing any less painful. It was more to do with a broken heart than anything else.’

Here, Mail blackjack online casino examines how doctors are now looking at new ways to treat broken heart syndrome (medically known as takotsubo cardiomyopathy)…

The singer, 56, died in her flat in Herne Hill, south-east London, 18 months after her beloved 17-year old son Shane killed himself

Veterinary nurse Sarah Woodward was at work when she received a phone call to say her best friend’s father had died. 

‘I’d known him for 45 years,’ says Sarah, from Worthing, West Sussex. ‘It was like losing my own father.’

Before she’d even put the phone down, a stabbing pain started in her chest. It then radiated through her back, into her jaw and down her left arm. 

She started to struggle to breathe and turned the colour of chalk — all classic signs of a heart attack.

Sarah, 54, was, however, exceptionally fit, doing at least ten hours of exercise a week, including kickboxing. She didn’t smoke, cooked from scratch every day with husband Kevin, 58, a gas engineer, and drank alcohol only once a week.

So it never crossed her mind that she was having a heart attack. Instead, she thought it was just a panic attack or that she’d pulled a muscle while exercising.

Veterinary nurse Sarah Woodward was at work when she received a phone call to say her best friend’s father had died. ‘I’d known him for 45 years,’ says Sarah, from Worthing, West Sussex. ‘It was like losing my own father’

A colleague, however, called an ambulance and, a few hours later, tests revealed it was something else entirely. Sarah had broken heart syndrome — where there is a sudden weakening of the muscle in the heart’s left ventricle, its main pumping chamber.

The mysterious and potentially fatal condition affects around 2,500 Britons a year and often occurs after a bereavement, hence its name. 

Around 90 per cent of patients are women aged 50 or over, and around one in 20 will die in hospital as a result.

In survivors, the heart’s shape and pumping capacity usually return to normal within three months, but many suffer long-term problems including chest pain, palpitations and online casinos breathlessness.

While symptoms such as sudden intense chest pain and shortness of breath mirror those of a heart attack, takotsubo is not caused by blocked arteries — as heart attacks generally are.

Instead, says Dr David Gamble, a clinical research fellow in cardiology at the University of Aberdeen, in around 70 per cent of cases a stressful event is to blame (in other cases, the cause is unclear).

This can be emotional, such as the death of a loved one or the end of a relationship, or physical, such as an assault or car crash.

Intriguingly, the stress needn’t be negative; happy occasions can also spark the condition. A 2016 study by University Hospital Zurich in Switzerland of 485 patients whose takotsubo had an emotional trigger found that while 96 per cent had experienced sad events, in the remaining 4 per cent it followed a joyful occasion such as a birthday party, winning at a casino or even a surprise marriage proposal.

That’s because all these events — and the stress response they trigger in the body — lead to a surge in adrenaline, a hormone released to prepare the body for ‘fight or flight’ which tells the heart to beat faster to boost blood flow to the brain and muscles.

In takotsubo syndrome, however, the rush of adrenaline shuts down the bottom of the left ventricle, its main pumping chamber, says Dr Alexander Lyon, an honorary consultant cardiologist at London’s Royal Brompton Hospital. Unable to contract, the bottom of the ventricle balloons outwards.

It never crossed her mind that she was having a heart attack. Instead, she thought it was just a panic attack or that she’d pulled a muscle while exercising

This characteristic shape is visible on X-rays of the heart and is key in diagnosing the syndrome. It’s what led Japanese researchers in 1990 to name it after a ‘takotsubo’ — a traditional narrow-necked, wide-bottomed pot used to trap octopus when fishing.

One mystery for doctors seeing those affected has been understanding why this rush of adrenaline affects some people, especially women, but not others.

Now scientists may have an answer which could pave the way for better treatments for the condition. In a study published in the journal Cardiovascular Research in June, Dr Lyon and colleagues at Imperial College London, investigated how human and rat heart cells responded to adrenaline.

They found heart cells were much more sensitive to adrenaline if they were also exposed to two molecules, microRNA-16 and microRNA-26a. In those that were, it took only about a fifth of the normal amount of adrenaline to stop them contracting.

MicroRNAs are small compounds that control protein production in cells. It’s not known from where these two emanate, but one theory is they are released by the brain in times of depression, anxiety and stress and travel in the blood to the heart.

Chronic stress may raise the levels to such an extent that some people are more likely to have a takotsubo attack when they later have a sudden shock.

Put another way, if two people experience the same rush of adrenaline after a shock, the person who has higher amounts of these microRNAs in their blood would be more likely to have a takotsubo attack, says Sian Harding, a professor of cardiac pharmacology involved in the study.

‘It may be that chronic stress is priming people to have this syndrome when they then suffer acute stress,’ she adds.

A study from Massachusetts General Hospital in March supports this theory. It found patients undergoing cancer scans who displayed heightened activity in their amygdala (the part of the brain that detects stress) were more likely to get broken heart syndrome over the next five years.

Dr Gamble says depression, anxiety and other mental health disorders are more common in those who experience takotsubo syndrome, and he is researching whether cognitive behavioural therapy (CBT) — a talking therapy that improves mental health — will aid recovery.

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Thirty patients will undergo 12 weeks of CBT and have their heart health compared with that of patients who are either prescribed a 12-week exercise programme (exercise lowers cholesterol, blood pressure and improves blood sugar regulation) or are simply treated with standard care.

Little is known about the best treatments for the syndrome, but there is some evidence ACE inhibitors, drugs prescribed to treat high blood pressure, are useful.

Genes and hormones may also play a role – genes, because the condition can run in families, and hormones because the overwhelming majority of cases are in post-menopausal women.

It is thought that male and female sex hormones may protect against the condition, leaving women more vulnerable after the menopause, when levels of oestrogen are lower. Higher levels of stress and anxiety in post-menopausal women may also help explain the link, says Dr Gamble.

One possibility in the future could be a test that measures levels of the two microRNAs identified in the recent Imperial study, to predict if a patient is at risk of experiencing a second attack of broken heart syndrome.

Similarly, drugs that block the action of the two microRNAs could provide a much-needed way of preventing recurrences.

Around one in five broken heart patients has a recurrence — and Sarah was one of them. After her first takotsubo attack she was prescribed ACE inhibitors, beta blockers (blood pressure drugs that block the effects of adrenaline), as well as blood thinners to reduce the risk of clots, which could cause a stroke.

On January 4, 2021, almost three years to the day since she collapsed at work, Sarah felt the same stabbing pain in her chest.

The trigger was a call from her GP in which he gave her some upsetting news about another – unrelated – health condition.

‘I remember sitting in the staff room, clutching my chest, crying and thinking I was going to die while looking at the waste-paper bin, which was overflowing. It was a feeling of utter resignation and hopelessness,’ says Sarah, who has three grown-up children.

Eight months on, she still has chest pain and breathlessness and while she still goes to the gym, she needs to nap before and intensive workouts are out of the question.

At the back of her mind is the fear she will have another attack. ‘The more I think about it,’ she says, ‘the more I worry that a third time might be the last.’

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Virginia Giuffre has claimed that Donald Trump did not participate in any underage sex while at the home of pedophile financier Jeffrey Epstein. 

In the newly released batch of documents, Giuffre said in a deposition that she didn’t believe the former President to have ‘participated in anything’. 

When asked if the former president was ‘a witness to the sexual abuse of minors’ while at the home of Epstein, Giuffre said she had never seen him at the property. 

She said: ‘I never saw or witnessed Donald Trump participate in those acts, but was he in the house of Jeffrey Epstein. I’ve heard he has been, but I haven’t seen him myself so I don’t know.’

Epstein’s Palm Beach villa was located just 1.5 miles from Trump’s Mar-a-Lago resort and the two men were friends in the 90s, with Trump flying on his plane, dubbed the ‘Lolita Express’ at least four times.   

Giuffre said in newly released deposition that she didn’t believe the former President, pictured here with Epstein, Maxwell, and Melania Trump, hadn’t participated in anything

The newly-unsealed deposition of Virginia Giuffre, seen her being interviewed by the BBC, were released by the court earlier today

When asked if the former president was ‘a witness to the sexual abuse of minors’ while at the home of Epstein, Giuffre said she had never seen him at the property

Giuffre had also added: ‘If you walked foot into Jeffrey Epstein’s house and you went in there and you continued to be an acquaintance of his, then you would have to know what was going on there.’

The former president was mentioned in the explosive 1,000 pages of documents released last week.

While his name had appeared throughout the documents, it has not implicated him in the pedophile financier’s debauchery or crimes. 

On Monday, documents relating to the case contained accusations from Epstein victim Sarah Ransom who claims Trump had sex with a friend of hers at Epstein’s Manhattan townhouse. 

Ransome claimed that Trump had sexual relations with ‘many girls,’ according to the documents. 

She described an unidentified friend, who she said was ‘one of the many girls that had sexual relations with Donald Trump.’ 

‘Mr. Trump definitely seemed to have a thing for her and she told me how he kept going on about how he liked her ‘pert nipples’. Donald Trump liked flicking and sucking her nipples until they were raw’, the document said. 

‘One evening when we were showering together she showed me her nipples. They looked incredibly painful as they were red and swollen and I remember wincing when I looked at them.

While his name had appeared throughout the documents, Trump has not been implicated in the pedophile financier’s debauchery or crimes 

Donald Trump and Epstein are pictured together at Trump’s Mar-a-Lago estate in 1997

Ransome claimed to have a friend who had slept with Donald Trump. Her description of their encounters is above

‘I also know she had sexual relations with Trump at Jeffery’s NY mansion on regular occasions as I once met Jen for coffee, just before she was going to meet Trump and Epstein together at his mansion,’ the emails claimed.

None of the women are named and Trump has repeatedly denied having any involvement in Epstein’s seedy lifestyle.

Steven Cheung, Trump spokesperson, hit back at the allegations, saying: ‘These baseless accusations have been fully retracted because they are simply false and have no merit.’ 

In Monday’s release of documents, it was also claimed that Epstein kept blackmail videos that showed Bill Clinton, Trump and Richard Branson having sex with woman he supplied them with. No such footage has ever been publicly uncovered. 

A spokesman for Branson’s company Virgin denied the allegations.

‘In a New Yorker report published in 2019, Ransome admitted that she had “invented” the tapes.

‘We can confirm that Sarah Ransome’s claims are baseless and unfounded.’

Unsealed documents last week revealed deposition by Johanna Sjoberg, an Epstein ‘victim’ who was allegedly recruited to work as a massage therapist, recalled meeting Trump during her visit to Atlantic City. 

She discussed a visit to a Trump Atlantic City Casino after a storm kept Epstein’s plane from landing in New York. It was her first time aboard Epstein’s plane.

Sarah Ransome, right, is pictured at Manhattan Federal Court after Ghislaine Maxwell’s sentencing

All of the filings come from a 2015 defamation lawsuit that Giuffre filed against Ghislaine Maxwell, who is seen here with pedophile Jeffrey Epstein

Her interview contains no suggestion Trump did anything inappropriate or visited Epstein’s private island, Little Saint James, where numerous orgies were alleged to have taken place.

Sjoberg even states that she did not give Trump a massage when asked.

‘We left from Palm Beach and landed in Atlantic City for a few hours because there was a storm in New York, and then got back on the plane a 10 few hours later and landed in Teterboro,’ said Sjoberg, 42.

‘Jeffrey said, ‘Great, we’ll call up Trump and we’ll go to’—I don’t recall the name of the casino, but—’we’ll go to the casino,’ Sjoberg said in her deposition, taken at a lawyer’s office in Florida in 2016. 

She said Giuffre, who was traveling with them, couldn’t go into the Casino.

‘She was underage. I did not know anything about how old you had to be to gamble legally. I just knew she could not get in because of an ID issue. So she and I did not gamble.’

The ended up walking around the casino because Giuffre either ‘didn’t have an ID or she was too young.’

She was also asked if she ever massaged Trump, and responded, ‘No.’

Trump spokesman Steven Cheung issued only a brief comment following the release of the first batch of documents last week. 

Trump was quoted speaking about Epstein favorably in a 2002 New York Magazine profile of Epstein that attempted to take stock of the high-flying money manager who traveled in top social circles and ran his business out of a private island in the Caribbean.  

‘I’ve known Jeff for 15 years. Terrific guy,’ Trump told the magazine. ‘He’s a lot of fun to be with. 

‘It is even said that he likes beautiful women as much as I do, and many of them are on the younger side. No doubt about it – Jeffrey enjoys his social life.’

Johanna Sjoberg’s unsealed deposition mentions a trip to Trump’s Atlantic City casino after a flight on Epstein’s jet

Epstein’s Upper East Side mansion, where many of the alleged crimes are said to have taken place

Trump also commented on Epstein from inside the Oval Office back in 2019, when the financier was facing charges for sexual abuse.

‘Well I knew him, like everybody in Palm Beach knew him.  The people in Palm Beach knew him. He was a fixture in Palm Beach,’ Trump continued. 

‘I had a falling out a long time ago with him,’ Trump said. ‘I don’t think I’ve spoken to him in 15 years.’

‘I wasn’t a fan , I was not a fan of his, that I can tell you,’ Trump added, without directly answering a question about the reason for the falling out.

All of the filings come from a 2015 defamation lawsuit that Giuffre filed against Maxwell. 

At the time, Giuffre had gone public with her claims against Prince Andrew, Maxwell and Epstein. 

She said she’d been sexually trafficked to the royal by Maxwell and Epstein, who she claimed abused countless other girls in similar ways. 

Maxwell, Epstein and Prince Andrew denied her allegations. 

Giuffre sued Maxwell for publicly labeling her a liar. The case was settled in 2017 – two years before Epstein was charged and later died by suicide – and before Maxwell’s arrest. 

They have become public now after repeated requests from the media and some of those caught up in the scandal, who pleaded for transparency from the court. 

What was expected was a list that unmasked the 187 Jane and John Does whose names were previously protected. 

The court has not fulfilled that request, and instead has published hundreds upon hundreds of pages where the names were previously redacted.  

New YorkVirginia Roberts GiuffreDonald Trump

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While many of us are in no way experts, and we just tag along to a casino to have a little fun, and see if fate happens to be on our side, there are actually games that you should prioritise when playing. Why, you ask? Well, many of these casino games actually come with odds or an edge that you can know about before you start playing. What an edge specifically means is, there is a degree or a percentage that works against you and is in favour of the casino winning. While the percentages can vary for each kind of game you play, it is important to know these values, especially if you are a beginner. It can help you give yourself the best chance of winning, which should be anyone’s goal when they play at land-based casinos or a casino online!

Casino Games With The Best Odds

Before we do start going into detail of the games with the best odds, it is important for you to know that not all casino games will be generous or favourable to you and your wallet. In fact, there is a saying that the house always wins, due to the odds that are against you before you even start playing. This is why many of the professionals are constantly forming strategies and methods of heightening their gambling techniques when they are in the game, which is what you will most likely do as you become more experienced. Nevertheless, use this article as means to become more familiar with the games that you happen to introduce to yourself along your journey.

The best games to play

So, when you first enter the casino hall, you need to remember one thing. Casino table games will always have better odds at winning than your standard slot games on the casino floor. There is not a ‘why’ to this reason, it is just the way it is, so always keep that in mind when you are making your selections. It certainly will help you when you build up the confidence of playing.

Blackjack: 49% chance of winning

Blackjack is a firm favourite of the gambling community, that there is no doubt. A simple game when you first contemplate playing it, but of course the further you get into it, the more opportunity you have if exploring betting opportunities that the game has to offer. This game has you playing against the dealer, and more than one person can play alongside you, but you will not be playing it out with each other, all that force will be directed to the dealer only. Whoever gets the closest hand to 21 is the winner and will of course win bets placed within the game. It could be you, it could be the dealer, but go into it knowingly, that the odds against you will be 51%, which is huge but still one of the best games out there for odds in your favour.

Winning blackjack will always be about the chance more than the skill, as the cards that happen to be in your hand you do not choose, it is all by random occurrence of course. Next time you happen to be in Vegas and pop down to the Venetian Resort, you should definitely be at a bit of an advantage, knowing which games pay you the best, right?

Craps: 50% chance of winning

Casino Games With The Best Odds

Craps is another game that you need to add to your list to play. The entire game is composed of you and other players, alongside a shooter that will roll the dice. The coming out roll, is the first roll that is played within the game essentially. For the shooter to win (who you are betting against), they need to roll a 7 or an 11. If you happen to make a pass line wager within the game, that possesses the odds of 50/50, which is the highest variant of odds in the game. There are more outcomes that are not so achievable and will have harder odds to achieve, so be less specific about the bets you want to make!

The worst games to play

Slots: 1 in 49.8 million chances

You heard us say that slots are not the best for you to try out earlier, and we meant it. Did you know that slot games are super difficult to win, as there are so many outcomes that could happen when you spin that wheel? Usually players often spend huge amounts to get just one win, which is never guaranteed as a large amount. Often it is the smaller payouts that have a better chance of winning, when you chose to play a low variance slot.

Big Wheel/ Wheel of Fortune: 26% chance of winning

When you play this game, you will bet on the wheel landing and stopping on a label that you prefer. It can be any money variants, or of course a Joker. Whatever the wheel stops on, is what you will win. Usually you can bet on super low limits, meaning it is possible to actually bet $1 and come out with more, but that is a small possibility. The payouts are pretty low, as yet the casino edge is high, so stay vigilant!

Thrill-seeking Coco Gauff has rocketed down the fastest serve of the women’s tournament en route to a rapid-fire entry to the Australian Open fourth round in Melbourne.

The reigning US Open champion cast friendship aside in a commanding 6-0 6-2 victory over fellow American Alycia Parks on Margaret Court Arena on Friday.

Gauff clocked one delivery at 199kph but was more pleased about converting all five break points against her 23-year-old compatriot.

“It’s tough because she’s a big server, so you’re not going to be able to strike as much as you want to,” said fourth seed Gauff.

“I did a good job with that and also mixing the height and the pace of the ball.

“She’s a big hitter, she likes it fast. So I was just trying my best to be aggressive when I could but also just playing with margin.”

Despite the one-sided victory, Gauff is predicting a bright future for Parks, who broke through to claim her maiden WTA Tour title last season in Lyon.

“I’m really happy with how I played today,” Gauff said.

“The scoreline says different, best online casino but she’s a tough player. She hits the ball big and I’ve known her since I was like nine or eight years old, probably even younger than that.

“This was our first time ever playing, juniors or pro, but hopefully we can have many more matches in the future.”

Riding a 10-match grand slam winning streak, and yet to lose in 2024 after taking the title in Auckland, Gauff has yet to drop a set this campaign and needed only a total of four hours, 20 minutes on court to make the second week.

Such efficiency has left the Crown-loving 19-year-old with more down time, and resisting the urge to hit the tables seems to have been more of a battle than her Open rivals so far.

“I have not gone to the casino yet, but I did last year and I won in roulette so I can see how people get addicted to that,” said Gauff, usa casino online who bungee-jumped off the 53-story-tall Auckland Sky Tower in new crypto casino Zealand.

“But here we’ve been doing mini golf, escape rooms, eating a lot and just watching the tennis.

“I always enjoy Melbourne. It reminds me of Florida a little bit with the weather and the crowds here are very nice.

“We love being here in Australia.”

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